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Test Code VB6 Vitamin B6 Profile (Pyridoxal 5-Phosphate and Pyridoxic Acid), Plasma

Important Note

  • Specimen must be protected from light.
  • Follow Specimen and Shipping requirements below.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Reporting Name

Vitamin B6 Profile (PLP and PA), P

Useful For

Determining vitamin B6 status, including in persons who present with progressive nerve compression disorders, such as carpal tunnel and tarsal tunnel syndromes

 

Determining the overall success of a vitamin B6 supplementation program

 

Diagnosis and evaluation of hypophosphatasia

 

Differentiating between hypophosphatasia or dietary supplementation as the likely cause of elevated pyridoxal-5'-phosphate (PLP) levels

Profile Information

Test ID Reporting Name Available Separately Always Performed
PLP Pyridoxal 5-Phosphate (PLP), P Yes Yes
B6PA Pyridoxic Acid (PA), P No Yes
Hunterdon Medical Center Note:

 PLP not individually orderable. Order as Vitamin B6 Profile.


Shipping Instructions


Ship specimen in amber vial to protect from light.



Specimen Required


Patient Preparation:

1. Patient should fast overnight (12-14 hours); infants-should have specimen collected before next feeding. Water may be taken as needed.

2. For 24 hours before specimen collection, patient must not take multivitamins or vitamin supplements.

Supplies: Amber Frosted Tube, 5 mL (T915)

Collection Container/Tube: 

Preferred: Green top (sodium or lithium heparin) or plasma gel separator (PST)

Acceptable: None

Submission Container/Tube: Amber vial

Specimen Volume: 1 mL

Collection Instructions:

1. Within 2 hours of collection, centrifuge at 4° C and aliquot into an amber vial.

2. Freeze immediately.


Specimen Minimum Volume

0.75 mL

Specimen Type

Plasma Heparin

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Heparin Frozen 29 days LIGHT PROTECTED

Day(s) Performed

Monday through Thursday, Saturday, Sunday

Reference Values

PYRIDOXAL 5-PHOSPHATE

5-50 mcg/L

 

PYRIDOXIC ACID

3-30 mcg/L

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82542

84207

LOINC Code Information

Test ID Test Order Name Order LOINC Value
B6PRO Vitamin B6 Profile (PLP and PA), P 95266-3

 

Result ID Test Result Name Result LOINC Value
61065 Pyridoxic Acid (PA), P 1688-1
4047 Pyridoxal 5-Phosphate (PLP), P 30552-4

Report Available

2 to 5 days