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HelpTest Code UBUP Buprenorphine and Norbuprenorphine, Random, Urine
Reporting Name
Buprenorphine and Metabolite, UPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Monitoring of compliance utilizing buprenorphine
Detection and confirmation of the illicit use of buprenorphine
Detection window* up to: 7 days
*These are approximate detection times for the drug or metabolites in urine. The actual detection time depends on dose, frequency of use, and individual metabolism.
Ordering Guidance
For screening buprenorphine alone, order BUPS / Buprenorphine Screen, Random, Urine.
For comprehensive opioid screening, order TOSU / Targeted Opioid Screen, Random, Urine.
For situations where chain of custody is required, a Chain of Custody Kit (T282) is available. For chain-of-custody testing, order BUPMX / Buprenorphine and Norbuprenorphine, Chain of Custody, Random, Urine.
Additional drug panels and specific requests are available. Call 800-533-1710 or 507-266-5700.
Additional Testing Requirements
If urine creatinine is required or adulteration of the sample is suspected, the following test should also be ordered, ADULT / Adulterants Survey, Random, Urine.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Plastic urine container
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative
Additional Information:
1. No specimen substitutions.
2. STAT requests are not accepted for this test.
3. Submitting less than 1 mL will compromise the ability to perform all necessary testing.
Specimen Minimum Volume
0.5 mL
Specimen Type
UrineSpecimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Urine | Refrigerated (preferred) | 14 days |
| Ambient | 14 days | |
| Frozen | 14 days |
Day(s) Performed
Monday through Friday
Reference Values
Negative (Positive results are reported with a quantitative result)
Cutoff concentrations by liquid chromatography tandem mass spectrometry:
Buprenorphine: 5.0 ng/mL
Norbuprenorphine: 2.5 ng/mL
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80348
G0480 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| BUPM | Buprenorphine and Metabolite, U | 69033-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 66200 | Buprenorphine | 3415-7 |
| 48296 | Norbuprenorphine | 49753-7 |
Report Available
3 to 5 daysForms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.