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Test Code CTDC Connective Tissue Diseases Cascade, Serum

Reporting Name

Connective Tissue Disease Cascade,S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Evaluation of patients with signs and symptoms compatible with connective tissue diseases

 

Initial evaluation of patients in clinical situations in which the prevalence of disease is low (6)

 

This test is not recommended for:

-Testing in clinical situations in which there is a high prevalence of connective tissue diseases (eg, rheumatology specialty practice)

-Follow-up evaluation of patients with known connective tissue diseases


Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Information: Centrifuge and aliquot serum into plastic vial.


Specimen Minimum Volume

0.7 mL

Specimen Type

Serum

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Day(s) Performed

Monday through Saturday

Reference Values

ANTINUCLEAR ANTIBODIES (ANA)

≤1.0 U (negative)

1.1-2.9 U (weakly positive)

3.0-5.9 U (positive)

≥6.0 U (strongly positive)

Reference values apply to all ages.

 

CYCLIC CITRULLINATED PEPTIDE ANTIBODIES, IgG

<20.0 U (negative)

20.0-39.9 U (weak positive)

40.0-59.9 U (positive)

≥60.0 U (strong positive) 

Reference values apply to all ages.

Special Instructions

Testing Algorithm

If antinuclear antibodies are greater than or equal to 3.0 U, then antibodies to double-stranded DNA (dsDNA), extractable nuclear antigen evaluation, ribosome P, and centromere are performed at an additional charge.

 

For more information see Connective Tissue Disease Cascade.

Profile Information

Test ID Reporting Name Available Separately Always Performed
ANA2 Antinuclear Ab, S Yes Yes
CCP Cyclic Citrullinated Peptide Ab, S Yes Yes
IM_01 Interpretation No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
CMA Centromere Ab, IgG, S Yes No
CASMT ANA2 Cascade No No
RIB Ribosome P Ab, IgG, S Yes No
ENAE Ab to Extractable Nuclear Ag Eval,S Yes No
ADNA1 dsDNA Ab, IgG, S Yes No

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86038

86200

83516-Centromere (if appropriate)

83516-Ribosome (if appropriate)

86225-ds-DNA AB IgG, Serum (if appropriate)

86235 x 6-RNP, Sm, SS-B, SS-A, Jo 1, and Scl 70 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CTDC Connective Tissue Disease Cascade,S 95267-1

 

Result ID Test Result Name Result LOINC Value
ANA2 Antinuclear Ab, S 94875-2
CCP Cyclic Citrullinated Peptide Ab, S 33935-8
IM_01 Interpretation 69048-7

Report Available

3 to 4 days