Test Code ATPCO Anal ThinPrep Cytology with Human Papillomavirus (HPV) Co-Test, Varies
Reporting Name
Anal ThinPrep Cytology w/HPV CoTestPerforming Laboratory
Mayo Clinic Laboratories in RochesterUseful For
Detection of malignant and premalignant changes
Detection of high-risk (HR) genotypes associated with the development of anal cancer
Individual genotyping of human papillomavirus (HPV)-16 and HPV-18, if present
May aid in triaging men and women with positive HR-HPV but negative anal Pap smear results
The cobas HPV test is not recommended for evaluation of suspected sexual abuse.
Necessary Information
1. The following information must accompany the specimen: Patient's name, medical record number, date of birth, sex, source (exact location and procedure used), date specimen was taken, name of ordering physician and pager number.
2. Submit any pertinent history or clinical information.
Specimen Required
Supplies: PreservCyt Vial (T536)
Specimen Type: Anus or rectum
Container/Tube: ThinPrep/PreservCyt solution vial
Specimen Volume: A minimum of 20 mL or entire collection
Collection Instructions:
1. Visualize the anal opening by retracting the buttocks.
2. Moisten Dacron or polyester swab past internal anal sphincter until it abuts the distal rectal wall (4-5cm).
3. Rotate the swab 360 degrees and maintain lateral pressure on swab against the walls of the anus. The swab should bow slightly due to the pressure.
4. While rotating, slowly withdraw the swab.
5. Rotate at least 10 times while withdrawing the swab. This should take 20 to 30 seconds.
6. Immediately place swab in the ThinPrep solution. Swish at least 20 to 30 seconds in the ThinPrep solution.
7. Dispose of the swab.
8. Tighten the cap so that the torque line on the cap passes the torque line on the vial.
9. Place labels on the vial and on the bag.
10. Bag ThinPrep specimens individually as they tend to leak during transport.
Specimen Type
VariesSpecimen Minimum Volume
See Specimen Required
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Varies | Ambient | 21 days | THIN PREP |
Day(s) Performed
Monday through Friday
Report Available
3 to 6 daysReference Values
ThinPrep ANAL SWAB
Satisfactory for evaluation. Negative for intraepithelial lesion or malignancy.
HUMAN PAPILLOMAVIRUS (HPV)
Negative for HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68
Testing Algorithm
When this test is ordered, a cytology screen and genotyping for high-risk human papillomavirus types will be performed.
Additional Tests
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
AHPV | HPV Anal Detect / Genotyping PCR | No | Yes |
Method Name
ATPCO: Light Microscopy
AHPV: Real-Time Polymerase Chain Reaction (PCR)
Test Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
ATPCO – 88112
AHPV - 87624
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
ATPCO | Anal ThinPrep Cytology w/HPV CoTest | In Process |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
614403 | Interpretation | 69965-2 |
614404 | Participated in the Interpretation | No LOINC Needed |
614405 | Report electronically signed by | 19139-5 |
614406 | Addendum | 35265-8 |
614407 | Gross Description | 22634-0 |
CY088 | Source | 22633-2 |
CY089 | Clinical History | 22636-5 |
614408 | Disclaimer | 62364-5 |
614409 | Case Number | 80398-1 |