Sign in →

Test Code ACHR Acetylcholine Receptor (Muscle AChR) Binding Antibody, Serum

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Reporting Name

ACh Receptor (Muscle) Binding Ab

Useful For

Supporting the diagnosis of autoimmune myasthenia gravis (MG) in adults and children

 

Distinguishing autoimmune from congenital MG in adults and children or other acquired forms of neuromuscular junction transmission disorders

 

An adjunct to the test for P/Q-type calcium channel binding antibodies as a diagnostic aid for Lambert-Eaton myasthenic syndrome


Ordering Guidance


Standalone testing (this test) is recommended in certain situations.

 

This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held for 1 week and assayed if sufficiently decayed or canceled if radioactivity remains.



Specimen Required


Patient Preparation: For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication.

Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL


Specimen Minimum Volume

1 mL

Specimen Type

Serum

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Day(s) Performed

Monday through Sunday

Reference Values

≤0.02 nmol/L

Testing Algorithm

This is the primary diagnostic test for myasthenia gravis.

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

Method Name

Radioimmunoassay (RIA)

CPT Code Information

86041

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ARBI ACh Receptor (Muscle) Binding Ab 97558-1

 

Result ID Test Result Name Result LOINC Value
8338 ACh Receptor (Muscle) Binding Ab 97558-1

Forms

If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.

Report Available

3 to 6 days